The band was formed in 1991 in Winnipeg, Manitoba as a duo consisting of singer-songwriters Kim Baryluk and Nancy Reinhold. Reinhold left the country in January 2003, and Baryluk continued as the creative force of the current band.
The Wyrd Sisters have released six independent recordings to both fan and critical acclaim. Three of the Wyrd Sisters' recordings have been nominated for Juno Awards (Canada's national music awards) in the Best Roots & Traditional Album - Group category: Inside The Dreaming, Raw Voice and Sin & Other Salvations.
In 2005 the band lost a legal action against the movie Harry Potter and the Goblet of Fire when the movie used the name Wyrd Sisters in the movie.